Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the Traumatic Coma Data Bank.

@article{Chesnut1993EarlyAL,
  title={Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the Traumatic Coma Data Bank.},
  author={Randall Matther Chesnut and S. Noelle Barton Marshall and Jan J. Piek and Barbara A. Blunt and Melville R. Klauber and L. F. Marshall},
  journal={Acta neurochirurgica. Supplementum},
  year={1993},
  volume={59},
  pages={
          121-5
        }
}
The outcome from severe head injury (GCS < or = 8 mmHg) was prospectively studied in patients from the Traumatic Coma Data Bank. We investigated the impact on outcome of hypotension (SBP < 90 mmHg) occurring from injury through resuscitation (early hypotension; N = 717) or in the Intensive Care Unit [ICU] (late hypotension; N = 493). Early hypotension occurred in 248 patients (34.6%) and was associated with a doubling of mortality (55% vs. 27%). If shock was present on admission, the mortality… CONTINUE READING
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