Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins.

Abstract

To find a common pathogenetic trait induced by polyQ-expanded proteins, we have used a conditional expression system in PC12 cells to tune the expression of these proteins and analyze the early and late consequences of their expression. We find that expression for 3 h of a polyQ-expanded protein stimulates cellular reactive oxygen species (ROS) levels and… (More)
DOI: 10.1074/jbc.M110.156521

Topics

  • Presentations referencing similar topics