Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins.


To find a common pathogenetic trait induced by polyQ-expanded proteins, we have used a conditional expression system in PC12 cells to tune the expression of these proteins and analyze the early and late consequences of their expression. We find that expression for 3 h of a polyQ-expanded protein stimulates cellular reactive oxygen species (ROS) levels and… (More)
DOI: 10.1074/jbc.M110.156521


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