Early and late effects of bone marrow-derived mononuclear cell therapy on lung and distal organs in experimental sepsis

@article{Ornellas2011EarlyAL,
  title={Early and late effects of bone marrow-derived mononuclear cell therapy on lung and distal organs in experimental sepsis},
  author={Debora Dos Santos Ornellas and Tatiana Maron-Gutierrez and Felipe Mateus Ornellas and Fernanda Ferreira Cruz and Gisele Pena de Oliveira and Isabela H. Lucas and L{\'i}via C. Fujisaki and Mariana Bleker de Oliveira and Walcy Paganelli Rosolia Teodoro and Vera L{\'u}cia Capelozzi and Paolo Pelosi and Marcelo Marcos Morales and Patricia R.M. Rocco},
  journal={Respiratory Physiology & Neurobiology},
  year={2011},
  volume={178},
  pages={304-314}
}
We tested the hypothesis that bone marrow-derived mononuclear cells (BMDMCs) at an early phase of cecal ligation and puncture (CLP)-induced sepsis may have lasting effects on: (1) lung mechanics and histology, (2) the structural remodelling of lung parenchyma, (3) lung, kidney, and liver cell apoptosis, and (4) pro- and anti-inflammatory cytokines and growth factors. At day 1, BMDMC significantly reduced mortality, as well as caspase-3, interleukin (IL)-6 and IL-1β, vascular endothelial growth… CONTINUE READING
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