Early and late changes in Pax6 expression accompany eye degeneration during cavefish development

@article{Strickler2001EarlyAL,
  title={Early and late changes in Pax6 expression accompany eye degeneration during cavefish development},
  author={Allen G. Strickler and Yoshiyuki Yamamoto and William R Jeffery},
  journal={Development Genes and Evolution},
  year={2001},
  volume={211},
  pages={138-144}
}
We have compared Pax6 expression during embryonic development in the eyed surface form (surface fish) and several different eyeless cave forms (cavefish) of the teleost Astyanax mexicanus. Despite lacking functional eyes as adults, cavefish embryos form small optic primordia, which later arrest in development and show various degrees of eye degeneration. The pattern of Pax6 mRNA expression was modified early and late during cavefish development. In early surface fish embryos, two bilateral Pax6… CONTINUE READING