Early and late B-cell development in the mouse.

  title={Early and late B-cell development in the mouse.},
  author={K. Rajewsky},
  journal={Current opinion in immunology},
  volume={4 2},
  • K. Rajewsky
  • Published 1992 in Current opinion in immunology
A common principle in B-cell development is the stringent selection of cells expressing appropriate antibody V regions as surface receptors. Cells failing to do so appear destined to rapid death. These life-death decisions are mediated by signals whose nature is not yet understood but whose generation involves immunoglobulin receptor complexes on B cells and B-cell progenitors.