Early and delayed cardioprotection by heat stress is mediated by calcitonin gene-related peptide

  title={Early and delayed cardioprotection by heat stress is mediated by calcitonin gene-related peptide},
  author={Qiu-jing Song and Y Li and Han-wu Deng},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Brief ischaemia or heat stress protects the myocardium against ischaemia-reperfusion injury. Heat stimulus evokes release of sensory nerve transmitters, including calcitonin gene-related peptide (CGRP). Since CGRP has been shown to play an important role in the mediation of ischaemic preconditioning, the present study examined whether early or delayed preconditioning induced by retrograde hyperthermic perfusion in vitro or by whole-body hyperthemia in vivo also involves endogenous CGRP… CONTINUE READING


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