Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatment.

@article{Wang1999EarlyAO,
  title={Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatment.},
  author={Shi Nan Wang and Robert Clark Lantz and Raymond F. Robledo and V Breceda and Allison Marie Hays and M. Witten},
  journal={Toxicologic pathology},
  year={1999},
  volume={27 3},
  pages={334-41}
}
In a simulated fire-related smoke exposure protocol, New Zealand white rabbits were utilized to investigate the potential effects of the 21-aminosteroid (lazaroid) analog U75412E on the early events of acute lung injury. Inhalation of a total of 1.6 mg/kg U75412E aerosolized at a rate of 1.53 mg/min at 0.5 hr after smoke exposure significantly attenuated… CONTINUE READING