Early alterations of brain cellular energy homeostasis in Huntington disease models.

@article{Mochel2012EarlyAO,
  title={Early alterations of brain cellular energy homeostasis in Huntington disease models.},
  author={Fanny Mochel and Brandon Durant and Xingli Meng and J. F. O'Callaghan and Hua Yu and Emmanuel Brouillet and Vanessa C. Wheeler and Sandrine Humbert and Raphael Schiffmann and Alexandra Durr},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 2},
  pages={1361-70}
}
Brain energy deficit has been a suggested cause of Huntington disease (HD), but ATP depletion has not reliably been shown in preclinical models, possibly because of the immediate post-mortem changes in cellular energy metabolism. To examine a potential role of a low energy state in HD, we measured, for the first time in a neurodegenerative model, brain levels of high energy phosphates using microwave fixation, which instantaneously inactivates brain enzymatic activities and preserves in vivo… CONTINUE READING