Early alterations of actin cytoskeleton in OK cells by opioids.

  title={Early alterations of actin cytoskeleton in OK cells by opioids.},
  author={Evangelia A. Papakonstanti and Efstathia Bakogeorgou and Elias Castanas and D. S. Emmanouel and Roland Hartig and Christos Stournaras},
  journal={Journal of cellular biochemistry},
  volume={70 1},
Recently we identified and characterized opioid binding sites in OK (opossum kidney) cells and observed decreased proliferation of these cells in response to opioids. In the present study we investigated the effects of opioids on the actin cytoskeleton and explored whether their antiproliferative action may relate to alterations in the distribution or the dynamics of actin microfilaments. Exposure of OK cells to the opioids alphaS1 casomorphin and ethylketocyclazocine resulted in a rapid and… CONTINUE READING
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