Early alterations in rat colonic mucosal cyclic nucleotide metabolism and protein kinase activity induced by 1,2-dimethylhydrazine.

@article{DeRubertis1980EarlyAI,
  title={Early alterations in rat colonic mucosal cyclic nucleotide metabolism and protein kinase activity induced by 1,2-dimethylhydrazine.},
  author={Frederick R. DeRubertis and Patricia A. Craven},
  journal={Cancer research},
  year={1980},
  volume={40 12},
  pages={4589-98}
}
The present study examined the acute effects of intrarectal administration of a single dose (25 mg/kg) of the colon carcin ogen 1,2-dimethylhydrazine (DMH) on DMA synthesis and cyclic nucleotide metabolism in rat colonie mucosa. DMH ini tially inhibited DMA synthesis (12 and 24 hr postinstillation) in distal colonie mucosa, at which time there were no… CONTINUE READING