Early age at menarche is associated with insulin resistance: a systemic review and meta-analysis

  title={Early age at menarche is associated with insulin resistance: a systemic review and meta-analysis},
  author={Zhipeng Zhang and Xianjin Hu and Changqiang Yang and Xiaoping Chen},
  journal={Postgraduate Medicine},
  pages={144 - 150}
ABSTRACT Objectives: We aimed to conduct a systemic review and meta-analysis of the relevant studies to further investigate the association between age at menarche and insulin resistance. Methods: PubMed, EMBASE, and Web of Science (SCI) databases were systemically searched until December 2017. Observational studies comparing the incidences of insulin resistance in patients with early, average, and late menarchal ages were identified. Weighted mean difference (WMD) for HOMA-IR scores and… 

Early menarche and its consequence in Korean female: reducing fructose intake could be one solution

  • J. KimJ. Lim
  • Medicine, Biology
    Clinical and experimental pediatrics
  • 2020
Decreasing one’s fructose intake might prevent early menarche as well as the development of obesity, insulin resistance, and cardiometabolic diseases in adulthood.

Modern dietary pattern is prospectively associated with earlier age at menarche: data from the CHNS 1997–2015

Higher adherence to modern dietary pattern during childhood is associated with an earlier menarcheal age than those in the lowest quartile, independent of premenarchesal body size.

Body composition and somatotype profile of pre and post menarche stage of Bengali school girls

Menarche is the occurrence of a first menstrual period in the female adolescent. The average age of onset of menarche is 12.4 years. Menarche signals maturation of the adolescent female body. It

Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood

Exposure to famine in fetal- and childhood- life period is associated with beta cell dysfunction in males and females without diabetes, but early life famine exposure was only associated with insulin resistance in non-diabetic females, indicating that malnutrition in early life period may offer a modifiable factor for type 2 diabetes development.

The influence of socioeconomic status on menarcheal age among Chinese school-age girls in Tianjin, China

Urban-rural differences played a more important role in the early onset of menarche than socioeconomic differences between families, and higher parental education was associated with earlier onset, but this association disappeared after adjustment for living residence.

Adverse effects of early puberty timing in girls and potential solutions.

Early menarche is associated with insulin-resistance and non-alcoholic fatty liver disease in adolescents with obesity

Girls with obesity presenting early menarche showed higher HOMA-IR levels, lower Matsuda Index and IGI values, and higher risk of NAFLD compared to girls without early menArche.



Systematic review and meta-analysis of age at menarche and risk of type 2 diabetes

An association between younger age at menarche and increased risk of type 2 diabetes mellitus is strongly supported and may help identify women with increasedrisk of developing T2DM.

Early menarche and blood pressure in adulthood: systematic review and meta-analysis

Early menarche is associated with hypertension among adult woman and it is unlikely that the observed association was to publication bias, as some studies have failed to observe such association.

Earlier Menarche Is Associated with Lower Insulin Sensitivity and Increased Adiposity in Young Adult Women

Early menarche is associated with lower insulin sensitivity and increased adiposity in young adulthood, potentially increasing the risk of type 2 diabetes and the metabolic syndrome later in life.

Early menarche is associated with metabolic syndrome and insulin resistance in premenopausal Korean women

Early menarche was associated with an increased risk of MetS and IR in premenopausal Korean women, and late menarches (>16 years) is not associated with metabolic syndrome after controlling for age and other confounders.

Age at menarche and its association with dysglycemia in Korean middle-aged women

Age at menarche is inversely associated with various forms of dysglycemia and may be helpful in predicting prediabetes and subsequent diabetes in Korean middle-aged women.

Age at menarche and metabolic markers for type 2 diabetes in premenopausal women: the BioCycle Study.

Early onset ofMenarche is associated with unfavorable metabolic phenotypes compared with average onset of menarche in healthy premenopausal women, including reduced insulin sensitivity and β-cell function and greater total and trunk fat.

Association between age at menarche and diabetes in Korean post-menopausal women: results from the Korea National Health and Nutrition Examination Survey (2007-2009).

The hypothesis that younger age at menarche is associated with increased diabetes prevalence in the Korean population is strengthened, as the observed association remained significant despite additional adjustment for body mass index and waist circumference.

Early menarche and the development of cardiovascular disease risk factors in adolescent girls: the Fels Longitudinal Study.

Girls with early menarche exhibited elevated blood pressure and glucose intolerance compared with later maturing girls, independent of body composition, which adversely affected cardiovascular disease risk factor changes independent of age and changes in FFM or PBF.

Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Findings support the hypothesis that earlier menarche is associated with greater risk for adult diabetes and cardiometabolic disease in the Brazilian context.