Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty

@inproceedings{Wright2015EarlyAD,
  title={Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty},
  author={Kristina M. Wright and Alyssa DiLeo and Michael A McDannald},
  booktitle={Front. Behav. Neurosci.},
  year={2015}
}
Early life adversity increases anxiety in adult rodents and primates, and increases the risk for developing post-traumatic disorder (PTSD) in humans. We hypothesized that early adversity impairs the use of learning signals -negative, aversive prediction errors-to reduce fear in uncertainty. To test this hypothesis, we gave adolescent rats a battery of adverse experiences then assessed adult performance in probabilistic Pavlovian fear conditioning and fear extinction. Rats were confronted with… CONTINUE READING
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