Early administration of methylprednisolone decreases apoptotic cell death after spinal cord injury.

@article{Vaquero2006EarlyAO,
  title={Early administration of methylprednisolone decreases apoptotic cell death after spinal cord injury.},
  author={Jes{\'u}s Vaquero and Mercedes Zurita and Santiago Oya and Concepci{\'o}n Aguayo and C E Plazas Bonilla},
  journal={Histology and histopathology},
  year={2006},
  volume={21 10},
  pages={1091-102}
}
The purpose of this study is to evaluate, in an experimental model of spinal cord injury (SCI), the presence of apoptotic cell death after trauma and if early administration of a single bolus of methylprednisolone (MP) influences apoptosis in the zone of trauma and in adjacent spinal cord segments. For this study, a total of 96 adult female Wistar rats were subjected to spinal contusion at the T6-T8 level, producing immediate paraplegia. Forty-eight animals (treated group) received a single… CONTINUE READING

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