Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart.

@article{Franchini2000EarlyAO,
  title={Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart.},
  author={Kleber Gomes Franchini and Adriana Souza Torsoni and Paulo Henrique Soares and M{\'a}rio Jos{\'e} Abdalla Saad},
  journal={Circulation research},
  year={2000},
  volume={87 7},
  pages={558-65}
}
Mechanical overload elicits functional and structural adaptive mechanisms in cardiac muscle. Signaling pathways linked to integrin/cytoskeleton complexes may have a function in mediation of the effects of mechanical stimulus in myocardial cells. We investigated the tyrosine phosphorylation and the assembly of the multicomponent signaling complex associated with focal adhesion kinase (Fak) and the actin cytoskeleton in the overloaded myocardium of rats. Pressure overload induced a 3-fold… CONTINUE READING

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