Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system.

@article{Shaked2004EarlyAO,
  title={Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system.},
  author={Iftach Shaked and Ziv Porat and Roman Gersner and Jonathan Kipnis and Michal Schwartz},
  journal={Journal of neuroimmunology},
  year={2004},
  volume={146 1-2},
  pages={84-93}
}
After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-mediated neuroprotective mechanism (adaptive immunity) that is amenable to boosting. We postulate that the beneficial or destructive outcome of the local microglial (innate… CONTINUE READING

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