Early activation of hemostasis during cardiopulmonary bypass: evidence for thrombin mediated hyperfibrinolysis.

@article{Teufelsbauer1992EarlyAO,
  title={Early activation of hemostasis during cardiopulmonary bypass: evidence for thrombin mediated hyperfibrinolysis.},
  author={H. Teufelsbauer and S Proidl and Miroslav Havel and Thomas Christian Vukovich},
  journal={Thrombosis and haemostasis},
  year={1992},
  volume={68 3},
  pages={
          250-2
        }
}
In 14 consecutive patients undergoing cardiopulmonary bypass for coronary bypass surgery the time course of coagulation and fibrinolysis markers were measured, e. g. plasma levels of thrombin-antithrombin III (TAT) complexes, cross-linked fibrin degradation products (XIFDP) and plasmin-alpha 2-antiplasmin complexes (PAP). TAT levels exceeded the 90% baseline percentile already during CPB (after opening of aortic clamp) in 10 patients, whereas PAP and XIFDP exceeded their 90% percentile in only… CONTINUE READING
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