Early activation defects in T lymphocytes from aged mice.

@article{Miller1997EarlyAD,
  title={Early activation defects in T lymphocytes from aged mice.},
  author={Richard L. Miller and Guillaume Garcia and Christopher J. Kirk and Jacek M. Witkowski},
  journal={Immunological reviews},
  year={1997},
  volume={160},
  pages={
          79-90
        }
}
Aging affects both calcium signals and protein kinase cascades in mouse T lymphocytes. The decline in calcium signal development largely represents differences between naive and memory T cells; the latter are resistant to increases in calcium concentration, and are more common in aged mice. Aging leads to declines in phosphorylation of a wide range of substrates in T cells stimulated by either anti-CD3 antibodies or by substances, such as phorbol myristate acetate (PMA) or ionomycin, that act… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 33 references

Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging.

The journals of gerontology. Series A, Biological sciences and medical sciences • 1997

Aging and the immune response . 31

EL Schneider, JW Rowe
Handbook of the biology of aging • 1996

A comparison of the interaction of She and the tyrosine kinase ZAP - 70 with the T cell antigen receptor zeta chain tyrosine - based activation motif

N Osman, SC Lucas, H Tbrner, D Cantrell
JBiolCheni • 1995