Early activation defects in T lymphocytes from aged mice.

  title={Early activation defects in T lymphocytes from aged mice.},
  author={Richard L. Miller and Guillaume Garcia and Christopher J. Kirk and Jacek M. Witkowski},
  journal={Immunological reviews},
Aging affects both calcium signals and protein kinase cascades in mouse T lymphocytes. The decline in calcium signal development largely represents differences between naive and memory T cells; the latter are resistant to increases in calcium concentration, and are more common in aged mice. Aging leads to declines in phosphorylation of a wide range of substrates in T cells stimulated by either anti-CD3 antibodies or by substances, such as phorbol myristate acetate (PMA) or ionomycin, that act… CONTINUE READING
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