Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis.

@article{Kurpius2006EarlyAM,
  title={Early activation, motility, and homing of neonatal microglia to injured neurons does not require protein synthesis.},
  author={Dana Kurpius and Nicholas Wilson and Leah Fuller and Amara Hoffman and Michael E. Dailey},
  journal={Glia},
  year={2006},
  volume={54 1},
  pages={58-70}
}
Neuronal injury in CNS tissues induces a rapid activation and mobilization of resident microglia (MG). It is widely assumed that changes in gene expression drive the morphological transformation of MG and regulate their mobilization during activation. Here, we used acutely excised neonatal rat brain slices to test whether the morphological transformation and homing of MG to injured neurons requires gene expression and de novo protein synthesis. Traumatic injury during excision of live brain… CONTINUE READING

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