Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome.

Abstract

A monoclonal antibody (HK-249) that recognizes a glucosamine sulfate alpha 1----4 glucuronic acid-containing determinant in heparan sulfate (HS) chains of a basement membrane-derived heparan sulfate proteoglycan identified and immunolocalized HS specifically to the amyloid deposits in neuritic plaques (NPs), congophilic angiopathy (CA), as well as in… (More)

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@article{Snow1990EarlyAO, title={Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome.}, author={Anson Snow and Howard Mar and David Nochlin and Ryuzo Sekiguchi and Koji Kimata and Y Koike and Teresa Wight}, journal={The American journal of pathology}, year={1990}, volume={137 5}, pages={1253-70} }