Early acarbose treatment ameliorates resistance of insulin-regulated GLUT4 trafficking in obese Zucker rats.

@article{Ledwig2002EarlyAT,
  title={Early acarbose treatment ameliorates resistance of insulin-regulated GLUT4 trafficking in obese Zucker rats.},
  author={Daniela Ledwig and Heidi M{\"u}ller and Hilmar Bischoff and J{\"u}rgen Eckel},
  journal={European journal of pharmacology},
  year={2002},
  volume={445 1-2},
  pages={141-8}
}
Genetically (fa/fa) obese Zucker rats represent an established model of impaired glucose tolerance, with profound insulin resistance. Acarbose, an inhibitor of alpha-glucosidases, attenuates postprandial blood glucose peaks, and improves glucose tolerance in these animals. In the present study, we have tested the hypothesis that the effect of acarbose is associated with improved glucose transporter isoform 4 (GLUT4) trafficking in muscle tissue. Acarbose was administered to Zucker rats as a… CONTINUE READING