Early abnormalities of post-sigh breathing in a mouse model of Rett syndrome.

@article{Voituron2010EarlyAO,
  title={Early abnormalities of post-sigh breathing in a mouse model of Rett syndrome.},
  author={Nicolas Voituron and S{\'e}bastien Zanella and Cl{\'e}ment Menuet and A M Lajard and Mathias Dutschmann and G{\'e}rard Hilaire},
  journal={Respiratory physiology & neurobiology},
  year={2010},
  volume={170 2},
  pages={173-82}
}
Rett syndrome is a neurodevelopmental disease accompanied by complex, disabling symptoms, including breathing symptoms. Because Rett syndrome is caused by mutations in the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2), Mecp2-deficient mice have been generated as experimental model. Males of Mecp2-deficient mice (Mecp2(-/y)) breathe normally at birth but show abnormal respiratory responses to hypoxia and hypercapnia from postnatal day 25 (P25). After P30, Mecp2(-/y) mice develop… CONTINUE READING

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