Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease

@inproceedings{McLamb2013EarlyWS,
  title={Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease},
  author={Brittney L. McLamb and Amelia J. Gibson and Elizabeth Lynne Overman and Chad H. Stahl and A J Moeser},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND AND AIMS The clinical onset and severity of intestinal disorders in humans and animals can be profoundly impacted by early life stress. Here we investigated the impact of early weaning stress in pigs on intestinal physiology, clinical disease, and immune response to subsequent challenge with enterotoxigenic F18 E. coli (ETEC). METHODOLOGY Pigs weaned from their dam at 16 d, 18 d, and 20 d of age were given a direct oral challenge of F18 ETEC at 26 d of age. Pigs were monitored from… CONTINUE READING
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