Early Treatment with Prednisolone or Acyclovir in Bell’s Palsy

@article{Sullivan2007EarlyTW,
  title={Early Treatment with Prednisolone or Acyclovir in Bell’s Palsy},
  author={Frank M. Sullivan and Iain R. C. Swan and Peter T. Donnan and Jillian M Morrison and Blair H Smith and Brian McKinstry and Richard J Davenport and Luke Vale and Janet E. Ciarkson and Vicky Hammersley and Sima Hayavi and Anne McAteer and Kevin Stewart and Fergus Daly},
  journal={Clinical Otolaryngology},
  year={2007},
  volume={32}
}
BACKGROUND Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain. METHODS We conducted a double-blind, placebo-controlled, randomized, factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of symptoms. Patients were randomly assigned to receive 10 days of treatment with prednisolone, acyclovir, both agents, or placebo. The primary… 

Efficacy of Prednisolone for Bell Palsy in Children

This study, although underpowered, does not provide evidence that early treatment with prednisolone improves complete recovery, and provides Class I evidence that for children with Bell palsy, prednisOLone does not significantly change recovery of complete facial function at 1 month.

Comparison of the Efficacy of Combination Therapy of Prednisolone - Acyclovir with Prednisolone Alone in Bell’s Palsy

The results of this study showed that the combined prednisolone and acyclovir therapy of patients with Bell’s palsy is far more effective than treatment with predisonsolone alone.

1396 Prednisolone for Bell’s Palsy in children: A randomised, double-blind, placebo-controlled, Multicentre Trial

The study does not provide evidence that early treatment with prednisolone improves complete recovery of children with Bell’s palsy, as the vast majority recover without treatment.

Steroid/Antiviral for the treatment of Bell's palsy: Double blind randomized clinical trial.

The combination of steroid and antiviral treatment increases the possibility of recovery in moderately severe to complete acute Bell's palsy.

Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy.

Treatment of BP with prednisolone is likely to be considered CE while treatment with acyclovir is highly unlikely, and further data on costs and utilities would be useful to confirm findings.

Single dose intravenous methyl prednisolone versus oral prednisolone in Bell's palsy: A randomized controlled trial

Intravenous methylprednisolone and oral prednisolones showed equivalent benefit in patients with acute Bell's palsy.

Bell’s palsy management: Acyclovir in combination with prednisolone versus prednisolone alone–a comparative study

Acyclovir and prednisolone in combination is more beneficial than prednisOLone alone in the treatment of Bell’s palsy.

Prednisolone in Bell's Palsy Related to Treatment Start and Age

  • S. AxelssonT. Berg A. Stjernquist-Desatnik
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2011
Treating patients with Bell's palsy within 48 hours of onset of palsy resulted in significantly higher complete recovery rates and less synkinesis compared with no prednisolone, whereas patients aged younger than 40 years did not differ with respect to prednisOLone treatment.

Evidence of ACTH and Prednisolone in Treatment of Bell’ s Palsy

Patents with new onset of facial nerve paralysis give higher recovery rate by using limited dose of prednisolone and tetracosactide acetate within 3 days of onset of symptoms together with physiotherapy program.
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