Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.

@article{Huang2017EarlyTC,
  title={Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.},
  author={Yong Huang and Sushila R. Dalal and Dionysios A. Antonopoulos and Nathaniel J. Hubert and Laura Harrell Raffals and Kyle Dolan and Christopher W Weber and Jeannette S. Messer and Bana Jabri and Albert Bendelac and A. Murat Eren and David T Rubin and Mitch L Sogin and Eugene B Chang},
  journal={Inflammatory bowel diseases},
  year={2017},
  volume={23 3},
  pages={
          366-378
        }
}
BACKGROUND Ulcerative colitis (UC) only involves the colonic mucosa. Yet, nearly 50% of patients with UC who undergo total proctocolectomy with ileal pouch anal anastomosis develop UC-like inflammation of the ileal pouch (pouchitis). By contrast, patients with familial adenomatous polyposis (FAP) with ileal pouch anal anastomosis develop pouchitis far less frequently. We hypothesized that pathogenic events associated with the development of UC are recapitulated by colonic-metaplastic… CONTINUE READING
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