Early T cell development can be traced in rat fetal liver.

  title={Early T cell development can be traced in rat fetal liver.},
  author={Luis M Alonso-C and Juan Jos{\'e} Fern{\'a}ndez Mu{\~n}oz and Agustı́n G. Zapata},
  journal={European journal of immunology},
  volume={30 12},
The degree of T cell commitment reached by cell precursors present in the fetal liver is a controversial issue. In the present work, the occurrence of fully T cell-committed progenitors among CD45+Thy-1+CD44+ 13-day-old rat fetal liver cells was demonstrated when limiting numbers of these cells in vitro reconstituted SCID mouse fetal thymic lobes providing single lineage-containing lobes for T, natural killer or dendritic cells. In addition, expression of rat pre-TCRalpha chain mRNA was… CONTINUE READING