Early Retinal Defects in Fmr1−/y Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype?

@inproceedings{Perche2018EarlyRD,
  title={Early Retinal Defects in Fmr1−/y Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype?},
  author={Olivier Perche and Chlo{\'e} Felgerolle and Maryvonne Ardourel and Audrey Bazinet and Arnaud Paris and Rafa{\"e}lle Rossignol and G{\'e}raldine Meyer-Dilhet and Anne-Laure Mausset-Bonnefont and Betty H{\'e}bert and David Laurenceau and C{\'e}line Mont{\'e}cot-Dubourg and Arnaud Menuet and J H Bizot and Jacques L. Pichon and Isabelle Ranchon-Cole and Sylvain Briault},
  booktitle={Front. Cell. Neurosci.},
  year={2018}
}
Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we recently demonstrated that retinas of adult… CONTINUE READING