Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice

@article{Allen2014EarlyPE,
  title={Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice},
  author={Joshua L. Allen and Xiufang Liu and Sean Pelkowski and Brian J Palmer and Katherine Conrad and Günter Oberdörster and Douglas Weston and Margot Mayer-Pr{\"o}schel and Deborah A. Cory-Slechta},
  journal={Environmental Health Perspectives},
  year={2014},
  volume={122},
  pages={939 - 945}
}
Background: Air pollution has been associated with adverse neurological and behavioral health effects in children and adults. Recent studies link air pollutant exposure to adverse neurodevelopmental outcomes, including increased risk for autism, cognitive decline, ischemic stroke, schizophrenia, and depression. Objectives: We sought to investigate the mechanism(s) by which exposure to ultrafine concentrated ambient particles (CAPs) adversely influences central nervous system (CNS) development… 
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Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse
TLDR
It is demonstrated that vulnerability of the brain to air pollution extends to gestation and produces features of several neurodevelopmental disorders in both sexes and the importance of the commonalities of components of particulate matter exposures as a source of neurotoxicity and common CNS alterations is highlighted.
Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders
TLDR
Findings suggest the human 3rd trimester equivalent as a period of potential vulnerability to neurodevelopmental toxicity to UFP, particularly in males, and point to the possibility that UFP air pollution exposure during periods of rapid neuro‐ and gliogenesis may be a risk factor not only for ASD, but also for other neuro developmental disorders that share features with ASD.
Effects of neonatal inhalation exposure to ultrafine carbon particles on pathology and behavioral outcomes in C57BL/6J mice
TLDR
The limited effect of neonatal exposure to ultrafine elemental carbon suggests this component of air pollution is not a substantial contributor to the behavioral alterations and neuropathology previously observed in response to ambient pollution particulate exposures.
The Impact of Inhaled Ambient Ultrafine Particulate Matter on Developing Brain: Potential Importance of Elemental Contaminants
TLDR
Elevations of brain Fe and S are consistent with potential ferroptotic, oxidative stress, and altered antioxidant capacity-based mechanisms of CAPs-induced neurotoxicity, supported by observations of increased serum oxidized glutathione and increased neuronal cell death in nucleus accumbens with no corresponding significant increase in caspase-3, in male brains following postnatal CAP exposures.
Gestational Exposure to Particulate Matter 2.5 (PM2.5) Leads to Spatial Memory Dysfunction and Neurodevelopmental Impairment in Hippocampus of Mice Offspring
TLDR
G gestational exposure to PM2.5 leads to spatial memory dysfunction and neurodevelopmental impairment by exerting effects on apoptotic and neuroinflammatory events, as well as the neurogenesis in hippocampus of mice offspring.
Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats
TLDR
Exposure to real-world levels of TRAP during gestation and early postnatal development modulate neurodevelopment, corroborating epidemiological evidence of an association between TRAP exposure and increased risk of NDDs.
Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment
TLDR
It is concluded that strategies are urgently required to reduce exposure to PM during this sensitive developmental period, as gestational PM exposure not only impacts neurodevelopment but may sensitise the brain to subsequent cognitive impairment.
Developmental exposure to low level ambient ultrafine particle air pollution and cognitive dysfunction
TLDR
Male‐specific learning and memory‐related deficits were seen and occurred even at relatively low level developmental UFP exposures, while females show alterations in motivational behaviors but not final performance, adding to the evidence suggesting the need to regulate UFP levels.
Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles.
TLDR
Combined developmental exposures to hyperoxia and CAPS leads to protracted and enhanced learning deficits consistent with cognitive inflexibility in males exclusively, suggesting deficits in acquisition of timing of the interval.
Air Pollution-Related Brain Metal Dyshomeostasis as a Potential Risk Factor for Neurodevelopmental Disorders and Neurodegenerative Diseases
TLDR
This review summarizes the current understanding of the extent to which the inhalational or intranasal instillation of metals reproduces in vivo the shared features of NDDs and NDGDs, including enlarged lateral ventricles, alterations in myelination, glutamatergic dysfunction, neuronal cell death, inflammation, microglial activation, oxidative stress, mitochondrial dysfunction, altered social behaviors, cognitive dysfunction, and impulsivity.
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Toxicology of ultrafine particles: in vivo studies
  • Güunter Oberdürster
  • Chemistry
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Ultrafine particles (less than 100 nm in diameter) are encountered in ambient air and at the workplace. Normal background levels in the urban atmosphere for ultrafine particles are in the range 1–4 ×…
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