Early Parkinson’s Disease-Like Pathology in a Transgenic Mouse Model Involves a Decreased Cst3 mRNA Expression But Not Neuroinflammatory Response in the Brain

@article{Korolenko2020EarlyPD,
  title={Early Parkinson’s Disease-Like Pathology in a Transgenic Mouse Model Involves a Decreased Cst3 mRNA Expression But Not Neuroinflammatory Response in the Brain},
  author={Tatyana A. Korolenko and Alexandra B Shintyapina and Victor M. Belichenko and Alexander B. Pupyshev and A. A. Akopyan and Larisa A. Fedoseeva and G. S. Russkikh and V. A. Vavilin and Michael V. Tenditnik and C-L Lin and Tamara G. Amstislavskaya and Maria A Tikhonova},
  journal={Medical University},
  year={2020},
  volume={3},
  pages={66 - 78}
}
Abstract Pathological aggregation and accumulation of α-synuclein in neurons play a core role in Parkinson’s disease (PD) while its overexpression is a common PD model. Autophagy-lysosomal pathways are general intraneural mechanisms of protein clearance. Earlier a suppressed autophagy in the brain of young transgenic mice overexpressing the А53Т-mutant human α-synuclein (mut(PD)) was revealed. Previous studies have recognized that Cystatin C displays protective activity against… 

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