Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. coli Disease Continues

@inproceedings{Benitz2011EarlyON,
  title={Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. coli Disease Continues},
  author={William E. Benitz},
  year={2011}
}
Transcriptome-wide profiling of the neonatal monocyte response to E. coli and S. epidermidis
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This first transcriptome-wide analysis of the neonatal monocyte response to E. coli confirms that exposure to HCA may impact on the development on neonatal immunity and provides novel insights into the functionality of preterm and term infant monocytes.
Atay et al. Serum Levels of C-reactive Protein and Pentraxin-3 in Neonatal Sepsis
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The main assistant techniques in diagnosis involve inflammatory markers such as white cell count and C-reactive protein (CRP), procalcitonin, fibrinogen, ceruloplasmin, haptoglobin, interleukin-6, serum amyloid-A (SAA), and pentraxin-3 (PTX-3) (4).
Evaluation of compliance with the 2017 Canadian Paediatric Society Position Statement for the management of newborns at risk for early-onset sepsis: A retrospective cohort study.
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The rate of noncompliance with the CPS recommendations was high (47%), mainly due to overzealous management, and future initiatives should aim at increasing compliance, particularly in newborns at lower EOS risk.
The role of CNSmacrophages in streptococcal meningoencephalitis
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This review summarizes the emerging knowledge on the sequence of reciprocal events between streptococci and CNS macrophages leading to host resistance, acute inflammation, changes in resident innate immune cells of the brain, and long-term neuronal damage.
Molecular profiling of acute chorioamnionitis-affected placentas : insights into genomic variation underlying a common preterm birth condition
.................................................................................................................................. iii Lay Summary
Population-based study of early-onset neonatal sepsis in Canada.
TLDR
A lower rate of early-onset neonatal sepsis is identified than historically suggested, with differing dominant organisms based on gestational ages and other factors, as well as high rates of resistance especially among E coli cases.
Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA)
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EOS is an independent factor associated with EOS and tauro-ω-muricholic acid within the ‘rare’ BA pool was significantly higher in EOS than in controls, and has diagnostic potential.
The phenotype and function of preterm infant monocytes: implications for susceptibility to infection
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Overall, preterm monocytes exhibit attenuated proinflammatory cytokine responses following stimulation by whole bacterial or specific microbial components in vitro, which cannot be explained by a lack of intracellular signaling events downstream of pattern recognition receptors.
Antenatal Screening for Group B Streptococcus in the Setting of Preterm Premature Rupture of Membranes: Empiric versus Culture-based Prophylaxis
TLDR
In pregnancies complicated by PPROM, babies of women who received culture-based IAP had no significant difference in EONS or GBS infection compared with infants of women with empiric IAP.
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