Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption

Abstract

HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. Breakdown in gut barrier integrity is linked to chronic inflammation and disease progression. However, the early effects of HIV on the gut epithelium, prior to the CD4+ T cell depletion, are not known. Further, the… (More)
DOI: 10.1371/journal.ppat.1004311

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@inproceedings{Hirao2014EarlyMS, title={Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption}, author={Lauren A. Hirao and Irina B Grishina and Olivier Bourry and William K. Hu and Monsicha Somrit and Sumathi Sankaran-Walters and Chris A. Gaulke and Anne N. Fenton and Jay A. Li and Robert W. Crawford and Frank Chuang and Ross P. Tarara and Maria L Marco and Andreas J B{\"a}umler and Holland R Cheng and Satya Dandekar}, booktitle={PLoS pathogens}, year={2014} }