Early Mammary Development: Growth Hormone and IGF-1

@article{Kleinberg2004EarlyMD,
  title={Early Mammary Development: Growth Hormone and IGF-1},
  author={David L. Kleinberg},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={2},
  pages={49-57}
}
  • D. Kleinberg
  • Published 2004
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.3 This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth… Expand
IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis
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The hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structure that lead the process of mammary gland development during puberty is proven. Expand
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This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer. Expand
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Prolactin and Mammary Gland Development
  • N. Horseman
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • 2004
TLDR
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TLDR
Analysis of early developmental processes in mammary tissue from mice carrying a targeted mutation in the IGF-I receptor gene suggests that IGF-dependent stimulation of cell cycle progression is more important to early mammary gland development than potential anti-apoptotic effects. Expand
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Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.
TLDR
It is suggested that GH can improve mammary development in PRLR(+/-) mice, but that it fails to enhance metabolic activity. Expand
Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland.
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Important functions for the family of IGFBPs during postnatal growth and differentiation of the mammary epithelium are suggested. Expand
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