Early Mammary Development: Growth Hormone and IGF-1

@article{Kleinberg2004EarlyMD,
  title={Early Mammary Development: Growth Hormone and IGF-1},
  author={David L. Kleinberg},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={2},
  pages={49-57}
}
  • D. Kleinberg
  • Published 2004
  • Biology
  • Journal of Mammary Gland Biology and Neoplasia
The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.3 This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth… 

IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis

The hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structure that lead the process of mammary gland development during puberty is proven.

Molecular regulators of pubertal mammary gland development

This work reviews the major molecular regulators of pubertal mammary gland development and identifies tissue-specific molecular networks that interpret signals from local cytokines/growth factors in both the epithelial and stromal microenvironments.

The Contribution of Growth Hormone to Mammary Neoplasia

This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.

Establishing a Framework for the Functional Mammary Gland: From Endocrinology to Morphology

Defining the hormonal control of ductal development should facilitate a better understanding of the mechanisms underlying mammary gland tumorigenesis and provide the opportunity to further delineate the regulation ofductal development.

Prolactin and Mammary Gland Development

  • N. Horseman
  • Biology
    Journal of Mammary Gland Biology and Neoplasia
  • 2004
Disruption of the genes for PRLand the PRL receptor, as well as those for transcription factors important in mammary gland regulation(Stat proteins), have provided a new set of animal models with which to study normal mammary glands development and the relationships of PRL to breastcarcinogenesis.

Pubertal Mammary Gland Development: Insights from Mouse Models

During puberty the mammary gland develops from a rudimentary tree to a branched epithelial network of ducts which can support alveolar development and subsequent milk production during pregnancy and

Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.

It is suggested that GH can improve mammary development in PRLR(+/-) mice, but that it fails to enhance metabolic activity.

Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland.

Important functions for the family of IGFBPs during postnatal growth and differentiation of the mammary epithelium are suggested.
...

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