Early-Life Stress Is Associated with Gender-Based Vulnerability to Epileptogenesis in Rat Pups

@inproceedings{Desgent2012EarlyLifeSI,
  title={Early-Life Stress Is Associated with Gender-Based Vulnerability to Epileptogenesis in Rat Pups},
  author={S{\'e}bastien Desgent and Sandra Duss and Nathalie T. Sanon and Pablo Lema and Maxime L{\'e}vesque and David H{\'e}bert and R. M. Rebillard and Karine Bibeau and Mich{\'e}le Brochu and Lionel Carmant},
  booktitle={PloS one},
  year={2012}
}
During development, the risk of developing mesial temporal lobe epilepsy (MTLE) increases when the developing brain is exposed to more than one insult in early life. Early life insults include abnormalities of cortical development, hypoxic-ischemic injury and prolonged febrile seizures. To study epileptogenesis, we have developed a two-hit model of MTLE characterized by two early-life insults: a freeze lesion-induced cortical malformation at post-natal day 1 (P1), and a prolonged hyperthermic… CONTINUE READING

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