Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice.

@article{McCann2016EarlyLifeIC,
  title={Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice.},
  author={Jessica R. McCann and S. Nicholas Mason and Richard L Auten and Joseph W. St. Geme and Patrick Casey Seed},
  journal={Infection and immunity},
  year={2016},
  volume={84 7},
  pages={2022-2030}
}
Accumulating evidence suggests a connection between asthma development and colonization with nontypeable Haemophilus influenzae (NTHi). Specifically, nasopharyngeal colonization of human infants with NTHi within 4 weeks of birth is associated with an increased risk of asthma development later in childhood. Monocytes derived from these infants have aberrant inflammatory responses to common upper respiratory bacterial antigens compared to those of cells derived from infants who were not colonized… CONTINUE READING
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