Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

@article{Spencer2006EarlyLifeIC,
  title={Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge},
  author={S J Spencer and Sheilagh Martin and Abdeslam Mouihate and Quentin J Pittman},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={1910-1918}
}
Many aspects of mammalian physiology are functionally immature at birth and continue to develop throughout at least the first few weeks of life. Animals are therefore vulnerable during this time to environmental influences such as stress and challenges to the immune system that may permanently affect adult function. The adult immune system is uniquely sensitive to immune challenges encountered during the neonatal period, but it is unknown where the critical window for this programming lies. We… CONTINUE READING

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