Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

@article{Milnerwood2010EarlyII,
  title={Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice},
  author={A. Milnerwood and C. M. Gladding and M. Pouladi and A. M. Kaufman and R. Hines and J. Boyd and R. Ko and O. C. Vasuta and R. Graham and M. Hayden and T. Murphy and L. Raymond},
  journal={Neuron},
  year={2010},
  volume={65},
  pages={178-190}
}
N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are poor therapeutic targets, due to their essential physiological role. Recent studies demonstrate that synaptic NMDAR transmission drives neuroprotective gene transcription, whereas extrasynaptic NMDAR activation promotes cell death. We report specifically increased extrasynaptic NMDAR expression, current, and associated… Expand
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