Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells.

@article{Andersson1998EarlyIP,
  title={Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells.},
  author={Asa Andersson and Wen Juan Dai and James P Di Santo and Frank Brombacher},
  journal={Journal of immunology},
  year={1998},
  volume={161 10},
  pages={5600-6}
}
NK cells are believed to play a mandatory role during the early phases of Listeria monocytogenes infection by producing IFN-gamma, which is required for the activation of macrophage effector functions. Mice deficient in the common cytokine receptor gamma-chain (gamma(c)-/-), which completely lack NK cells, were used to examine whether NK cells were essential for resistance to Listeria infection in vivo. Surprisingly, infected gamma(c)-/- mice showed normal innate immunity and macrophage… CONTINUE READING
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