Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.

  title={Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.},
  author={Catherine A. Brennan and Francisco Javier Ibarrondo and Catherine A. Sugar and Mary Ann Hausner and Roger Y W Shih and Hwee L. Ng and Roger Detels and Joseph B. Margolick and Charles R. Rinaldo and John P. Phair and Lisa Paula Jacobson and Otto O Yang and Beth D. Jamieson},
  journal={Journal of virology},
  volume={86 19},
Although HLA-B*57 (B57) is associated with slow progression to disease following HIV-1 infection, B57 heterozygotes display a wide spectrum of outcomes, including rapid progression, viremic slow progression, and elite control. Efforts to identify differences between B57-positive (B57(+)) slow progressors and B57(+) rapid progressors have largely focused on cytotoxic T lymphocyte (CTL) phenotypes and specificities during chronic stages of infection. Although CTL responses in the early months of… CONTINUE READING
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