Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.

@article{Brennan2012EarlyHC,
  title={Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.},
  author={Catherine A. Brennan and Francisco Javier Ibarrondo and Catherine A. Sugar and Mary Ann Hausner and Roger Y W Shih and Hwee L. Ng and Roger Detels and Joseph B. Margolick and Charles R. Rinaldo and John P. Phair and Lisa Paula Jacobson and Otto O Yang and Beth D. Jamieson},
  journal={Journal of virology},
  year={2012},
  volume={86 19},
  pages={10505-16}
}
Although HLA-B*57 (B57) is associated with slow progression to disease following HIV-1 infection, B57 heterozygotes display a wide spectrum of outcomes, including rapid progression, viremic slow progression, and elite control. Efforts to identify differences between B57-positive (B57(+)) slow progressors and B57(+) rapid progressors have largely focused on cytotoxic T lymphocyte (CTL) phenotypes and specificities during chronic stages of infection. Although CTL responses in the early months of… CONTINUE READING
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Publications referenced by this paper.
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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 7 Excerpts
Highly Influenced

The Multicenter AIDS

R Detels
Cohort Study, • 2012

CD4 T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

H Chen
J. Clin. Invest • 2011
View 2 Excerpts

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