Early Growth Inhibition Is Followed by Increased Metastatic Disease with Vitamin D (Calcitriol) Treatment in the TRAMP Model of Prostate Cancer

@inproceedings{Ajibade2014EarlyGI,
  title={Early Growth Inhibition Is Followed by Increased Metastatic Disease with Vitamin D (Calcitriol) Treatment in the TRAMP Model of Prostate Cancer},
  author={Adebusola Alagbala Ajibade and Jason S. Kirk and Ellen Karasik and Bryan M. Gillard and Michael T. Moser and Candace S. Johnson and Donald L. Trump and Barbara A. Foster},
  booktitle={PloS one},
  year={2014}
}
The active metabolite of vitamin D3, 1,25-dihydroxyvitamin D3 (calcitriol) has antiproliferative effects in non-aggressive prostate cancer, however, its effects in more aggressive model systems are still unclear. In these studies, effects of calcitriol and a less-calcemic vitamin D analog, QW-1624F2-2 (QW), were tested in vivo, using the aggressive autochthonous transgenic adenocarcinoma of mouse prostate (TRAMP) model. To study prevention of androgen-stimulated prostate cancer, vehicle… CONTINUE READING