Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

  title={Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock},
  author={E Ivers and B{\'e}rang{\`e}re Guyen and S Uzanne H Avstad and Richard Essler and Ernhard K Noblich and E Dward P Eterson},
  journal={The New England Journal of Medicine},
Background Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit. Methods We randomly assigned patients who arrived at an urban emergency department with severe sepsis or septic shock to… 

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