Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.

  title={Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.},
  author={S. Nakada and Y. Katsuki and I. Imoto and T. Yokoyama and M. Nagasawa and J. Inazawa and S. Mizutani},
  journal={The Journal of clinical investigation},
  volume={116 1},
  • S. Nakada, Y. Katsuki, +4 authors S. Mizutani
  • Published 2006
  • Biology, Medicine
  • The Journal of clinical investigation
  • Topoisomerase II (Topo II) inhibitors are cell cycle-specific DNA-damaging agents and often correlate with secondary leukemia with chromosomal translocations involving the mixed-lineage leukemia/myeloid lymphoid leukemia (MLL) gene on chromosome 11 band q23 (11q23). In spite of the clinical importance, the molecular mechanism for this chromosomal translocation has yet to be elucidated. In this study, we employed 2-color FISH and detected intracellular chromosomal translocations induced by… CONTINUE READING
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