Early Fecal Microbiota Transplantation Improves Survival in Severe Clostridium difficile Infections.

@article{Hocquart2018EarlyFM,
  title={Early Fecal Microbiota Transplantation Improves Survival in Severe Clostridium difficile Infections.},
  author={Marie Hocquart and Jean-Christophe Lagier and Nadim Cassir and Nadia Saidani and Carole Eldin and Jad Kerbaj and Marion Delord and Camille Valles and Philippe Brouqui and Didier Raoult and Matthieu Million},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2018},
  volume={66 5},
  pages={645-650}
}
Background Severe Clostridium difficile infections (CDIs) are associated with a high mortality rate despite medical and/or surgical treatment. Fecal microbiota transplantation (FMT) prevents recurrences, but its effect on survival has been shown only in patients with O27 ribotype CDI. Here, we investigated whether early FMT could improve survival in hospitalized CDI patients, particularly those with severe infection. Methods We performed a retrospective cohort study between May 2013 and April… CONTINUE READING