Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus

@article{Joksovic2015EarlyET,
  title={Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus},
  author={Pavle M. Joksovic and Nadia Lunardi and Vesna Jevtovi{\'c}-Todorovi{\'c} and Slobodan M Todorovic},
  journal={Molecular Neurobiology},
  year={2015},
  volume={52},
  pages={952-958}
}
Recent evidence supports the idea that common general anesthetics (GAs) such as isoflurane (Iso) and nitrous oxide (N2O; laughing gas) are neurotoxic and may harm the developing mammalian brain, including the thalamus; however, to date very little is known about how developmental exposure to GAs may affect synaptic transmission in the thalamus which, in turn, controls the function of thalamocortical circuitry. To address this issue we used in vitro patch-clamp recordings of evoked inhibitory… CONTINUE READING