Early Diagnosis of Human Lassa Fever by Elisa Detection of Antigen and Antibody

@article{Jahrling1985EarlyDO,
  title={Early Diagnosis of Human Lassa Fever by Elisa Detection of Antigen and Antibody},
  author={PeterB. Jahrling and B H Niklasson and J. N. McCormick},
  journal={The Lancet},
  year={1985},
  volume={325},
  pages={250-252}
}
Sequential serum samples, beginning on the day of hospital admission, from three patients with Lassa fever were tested for the presence of Lassa-virus antigens and antibodies by means of an enzyme-linked immunosorbent assay. Lassa-virus antigens were detected in the first serum sample from each patient, thus providing an early definitive diagnosis. In contrast, seroconversion was not detectable by ELISA or indirect fluorescent antibody techniques until 3 days or more after admission. The… CONTINUE READING