Early Detection of Ventilation-Induced Brain Injury Using Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: An In Vivo Study in Preterm Lambs

@inproceedings{Skild2014EarlyDO,
  title={Early Detection of Ventilation-Induced Brain Injury Using Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: An In Vivo Study in Preterm Lambs},
  author={B{\'e}atrice Ski{\"o}ld and Qizhu Wu and Stuart Brian Hooper and Peter G Davis and R. Mcintyre and Mary Tolcos and James Pearson and Ruth Vreys and Gary F. Egan and Samantha K. Barton and Jeanie L. Y. Cheong and Graeme Roger Polglase},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND AND AIM High tidal volume (VT) ventilation during resuscitation of preterm lambs results in brain injury evident histologically within hours after birth. We aimed to investigate whether magnetic resonance spectroscopy (MRS) and/or diffusion tensor imaging (DTI) can be used for early in vivo detection of ventilation-induced brain injury in preterm lambs. METHODS Newborn lambs (0.85 gestation) were stabilized with a "protective ventilation" strategy (PROT, n = 7: prophylactic… CONTINUE READING

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