Early Degenerative Changes in Transgenic Mice Expressing Mutant Huntingtin Involve Dendritic Abnormalities but No Impairment of Mitochondrial Energy Production

@article{Guidetti2001EarlyDC,
  title={Early Degenerative Changes in Transgenic Mice Expressing Mutant Huntingtin Involve Dendritic Abnormalities but No Impairment of Mitochondrial Energy Production},
  author={Paolo Guidetti and Vinod D. Charles and Edison Chen and Poovendhree. Reddy and Jeffrey H. Kordower and William O. Whetsell and Robert M. Schwarcz and Danilo A. Tagle},
  journal={Experimental Neurology},
  year={2001},
  volume={169},
  pages={340-350}
}
Mitochondrial defects, which occur in the brain of late-stage Huntington's disease (HD) patients, have been proposed to underlie the selective neuronal loss in the disease. To shed light on the possible role of mitochondrial energy impairment in the early phases of HD pathophysiology, we carried out Golgi impregnation and quantitative histochemical/biochemical studies in HD full-length cDNA transgenic mice that were symptomatic but had not developed to a stage in which neuronal loss could be… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 80 CITATIONS

Similar Papers

Loading similar papers…