Early Cytokine Release in Response to Live Borrelia burgdorferi Sensu Lato Spirochetes Is Largely Complement Independent

@inproceedings{Sandholm2014EarlyCR,
  title={Early Cytokine Release in Response to Live Borrelia burgdorferi Sensu Lato Spirochetes Is Largely Complement Independent},
  author={Kerstin Sandholm and Anna J Henningsson and Susanne S{\"a}ve and Sven Bergstr{\"o}m and Pia Forsberg and Nina Jonsson and Jan Ernerudh and Kristina Nilsson Ekdahl and Geetha P. Bansal},
  booktitle={PloS one},
  year={2014}
}
AIM Here we investigated the role of complement activation in phagocytosis and the release of cytokines and chemokines in response to two clinical isolates: Borrelia afzelii K78, which is resistant to complement-mediated lysis, and Borrelia garinii LU59, which is complement-sensitive. METHODS Borrelia spirochetes were incubated in hirudin plasma, or hirudin-anticoagulated whole blood. Complement activation was measured as the generation of C3a and sC5b-9. Binding of the complement components… CONTINUE READING
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Information processing during phagocytosis

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