Early Childhood Neurodevelopment After Intrauterine Growth Restriction: A Systematic Review

  title={Early Childhood Neurodevelopment After Intrauterine Growth Restriction: A Systematic Review},
  author={Terri A Levine and Ruth Eckstein Grunau and Fionnuala M Mcauliffe and Ragamallika Pinnamaneni and Adrienne M Foran and Fiona Alderdice},
  pages={126 - 141}
BACKGROUND AND OBJECTIVE: Children who experienced intrauterine growth restriction (IUGR) may be at increased risk for adverse developmental outcomes in early childhood. The objective of this study was to carry out a systematic review of neurodevelopmental outcomes from 6 months to 3 years after IUGR. METHODS: PubMed, Embase, PsycINFO, Maternity and Infant Care, and CINAHL databases were searched by using the search terms intrauterine, fetal, growth restriction, child development… 

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Children with intrauterine growth retardation demonstrated a specific profile of neurocognitive difficulties at school age, accounting for lower school achievements, and the best perinatal parameter predictive of neurodevelopment and IQ was the Cephalization Index.

Six-Year Follow-Up of Children With Intrauterine Growth Retardation: Long-Term, Prospective Study

A specific profile of difficulties in coordination, lateralization, spatial and graphomotor skills, and abundance of associated movements is typical of the children with intrauterine growth retardation and hints at possible later learning disabilities.

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The neuropsychological profile at 9 years of age indicates that late-onset intrauterine growth restriction compromises frontal network functioning, reaffirm that functional coherence depends on preestablished structural growth and reorganization of the central nervous system.

Impact of intrauterine growth restriction on neurodevelopmental and growth outcomes in very low birthweight infants

The impact of intrauterine growth restriction (IUGR) in very low birthweight preterm infants weighing ≤ 1250g was determined by comparing longitudinal growth and neurodevelopmental outcome to an

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