Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

  title={Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease},
  author={Michael S. Unger and Julia Marschallinger and Julia Kaindl and Corinna H{\"o}fling and Steffen Rossner and Michael T Heneka and A Van der Linden and Ludwig Aigner},
  booktitle={Molecular Neurobiology},
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the Western world and is characterized by a progressive loss of cognitive functions leading to dementia. One major histopathological hallmark of AD is the formation of amyloid-beta plaques, which is reproduced in numerous transgenic animal models overexpressing pathogenic forms of amyloid precursor protein (APP). In human AD and in transgenic amyloid plaque mouse models, several studies report altered rates of adult… CONTINUE READING
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