Early Bactericidal Activity of Amoxicillin in Combination with Clavulanic Acid in Patients with Sputum Smear-positive Pulmonary Tuberculosis

  title={Early Bactericidal Activity of Amoxicillin in Combination with Clavulanic Acid in Patients with Sputum Smear-positive Pulmonary Tuberculosis},
  author={Frederick A. Sirgel Amor Venter Peter R. Donald},
  journal={Scandinavian Journal of Infectious Diseases},
  pages={466 - 469}
  • Peter R. Donald, Frederick A. Sirgel, Amor Venter,
  • Published 1 January 2001
  • Medicine, Biology
  • Scandinavian Journal of Infectious Diseases
The early bactericidal activity (EBA) of an antituberculosis agent is the rate of decrease in viable colony-forming units (CFU) per milliliter of sputum during the first 2 d of treatment of patients with previously untreated smear-positive pulmonary tuberculosis. The objective of this open randomized study was to evaluate the EBA of the combination of amoxicillin 3 g and clavulanic acid 750 mg. Ten patients with a mean age of 34 y and a mean weight of 56 kg received amoxicillin/clavulanic acid… 

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