Early Appearance of Neutralizing Immunoglobulin G3 Antibodies Is Associated With Chikungunya Virus Clearance and Long-term Clinical Protection

@inproceedings{Kam2012EarlyAO,
  title={Early Appearance of Neutralizing Immunoglobulin G3 Antibodies Is Associated With Chikungunya Virus Clearance and Long-term Clinical Protection},
  author={Y. L. K. Kam and Diane Simarmata and Angela L. P. Chow and Zhisheng Her and Terk-Shin Teng and Edward K. S. Ong and Laurent R{\'e}nia and Yee Sin Leo and Lisa F P Ng},
  booktitle={The Journal of infectious diseases},
  year={2012}
}
BACKGROUND Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. Although infected individuals clear the virus from the blood, some develop debilitating and prolonged arthralgia. METHODS We investigated specificity and strength of antibody responses in a longitudinal study on CHIKV-infected patients and analyzed their association with viral load, cytokine profile, and severity. RESULTS We found that… CONTINUE READING

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